High level independent criminals of any organized faction and working for themselves.
| Name | Active Years | Brief Bio | Status |
|---|---|---|---|
| Alec Penn / Count Gordon | 1932 | Alec Penn was an international swindler, murderer and forger with numerous aliases. | Free |
| Old Mike | 1933 | A ship captain and smuggler who teamed up with Stooge Viller. | Dead |
| Mad Doc Hump | 1934 | A mad scientist crime doctor who loved to "experiement". | Dead |
| The Blank | 1937 | Masked villian who slowly killed off the Supeena gang. The Blank was finally revealed to be Frank Redrum. | Jailed |
| Marro | 1938 | Jealous associate of poison gas producer Karpse. | Free |
| Karpse | 1938 | Supplied poison gas to foreign powers. | Dead |
| Halone | 1938 | Agent for a foreign power obtaining poison gas from Karpse. | Dead |
| Professor M. Emirc | 1939 | An inventor who specialized in rigged weapons for criminals. | Unknown |
| Black Pearl | 1940 | Black Pearl is the pseudonym of Pearl Erad, a creator of exploding war machines. | Jailed |
| Krome | 1940, 1941 | A maker of deadly Toy's, Krome creating a murdering business called Crime Inc. | Dead |
| The Mole | 1941, 2012, 2013 | An ex-counterfeiter who provided shelter for criminals and then killed them. | Free |
| Cal Bullet Jr. | 1942 | Chemical genius/traitor who murdered his own father and worked with Pruneface. | Dead |
| Clara | 1942 | Jukebox operator and go between for Pruneface and Cal Bullet. | Jailed |
| Agent 20 | 1942 | Pruneface accomplice who was trapped with him in a house surrounded by Police. | Dead |
| Pruneface | 1942, 1983, 1986*, 1987, 1999 | Nazi German agent who led a sabotage ring against the United States. | Dead |
| Tojo | 1942 | Japanese Spy associate of Pruneface. He was captured by Dick Tracy. | Jailed |
| Mrs. Pruneface | 1943 | Wife of Pruneface who sought revenge on Dick Tracy for her husbands death. | Dead |
| Flattop Jones | 1943, 1944 | Professional hitman hired to kill Dick Tracy. | Dead |
| Zola | 1944 | One of three blackmarketers who hired Flattop to kill Dick Tracy. | Jailed |
| Bud Jenkins | 1944 | 10 year old pickpocket and blackmailer of Flattop Jones. | Dead |
| The Brow | 1944 | German spy ring master. | Dead |
| Influence | 1946, 1947 | Influence is a hypnotist, legbreaker and thief who uses the mind to his advantage. | Jailed |
| Crewy Lou Brown | 1951 | Professional photographer who would kidnap Bonnie Braids. | Dead |
| Spinner Record | 1951 | Owned a music store and tried to rob $500,000 from police safe. | Jailed |
| Flattop Jones Jr. | 1956 | Son of the hitman Flattop, Junior kept Tracy on his toes for nearly a year. | Dead |
| The Brush | Dick Tracy Stories – 1962 | Ran a racket claiming a condition from radioactive fallout. | Dead |
| Dr. Olga | 1963 | A towering doctor who developed a heart transplant producer for evil purposes. | Jailed |
| Eric Von Rhino | 1964 | Head of the Von Rhino spy ring looking for aviatrix found in ice. | Dead |
| Trinka | 1964 | An enemy aviatrix who shot down Lita Flite in 1937. | Dead |
| Haf and Haf | 1966, 1967, 1978, 1990, 2003* | A two faced criminal and murderer who faced off with Tracy several times. | Unknown |
| Chin Chillar | 1967, 1968 | Fashion forward man who stole a Space Coupe with his wife Notta. | Dead |
| Dr. Freezedrei | 1983, 1987 | Cryogenic's scientist who brought Pruneface back to life. | Dead |
| Egan Oipse | 1985 | A man of espionage who tried to sell Plutonium 239 to Angeltop Jones. | Dead |
| Mistress of Death | 2001 | A shake down artist who preached for donations. | Dead |
| Gnash | 2004 | Led a team of foreign terrorists who took hostages at City U College. | Jailed |
| Mr. Pixel | 2005 | A high-tech criminal hacker | Free |
| Al Kinda | 2006 | A terrorist cell leader who plotted to steal cash from lottery winners. | Dead |
| Gretchen Von KluMeister | 2007 | Granddaughter of an ex-East German spy with her own plans. | Dead |
| Coldspot | 2007 | A Russian spy chief with a longing for the Cold War days. | Free |
| Virgil Ohso | 2009, 2010 | A foreign embezzeller with a grudge against an Ambassador. | Jailed |
| Dr. Mordred | 2010, 2011 | A notorious serial killer who spent stormy night with Tracy. | Dead |
| Morning Gloria | 2010, 2011 | A long wanted bomb maker who moved in next to the Plentys. | Jailed |
| Blaze Rize | 2010, 2011, 2012 | Twin sister of Hot Rize a top player in the new Mr. Crime organization. | Free |
| Abner Kadaver | 2010, 2011, 2012 | An assassin straight out of a horror movie. | Jailed |
| Phishface | 2010, 2011, 2012 | A sushi loving criminal who ran an online phishing racket. | Jailed |
| Blackjack | 2012, 2013 | A robin hood style bank robber obsessed with Dick Tracy. | Free |
| The Jumbler | 2013 | A puzzle slinging criminal who challenged Dick Tracy's wits. | Jailed |
| Silver Nitrate | 2014 | A theater based con man and murderer. | Free |